ЛТ при РПК в большинстве случаев носит паллиативный характер, однако метод может иметь значение при использовании его в предоперационном периоде. Паллиативный эффект может быть достигнут приблизительно у 10—20% больных при использовании 5-ФУ. В нескольких клинических исследованиях продемонстрировано повышение частоты достижения эффекта и облегчения тяжести симптомов заболевания при сочетании 5-ФУ с лейковорином, однако улучшения показателей выживаемости не выявлено ни в одном из них [44—50]. Иринотекан (СРТ-11) был одобрен Управлением по контролю за качеством пищевых продуктов и лекарственных препаратов (FDA) США для лечения пациентов, рефрактерных к ХТ 5-ФУ [51—54]. Участие пациентов в клинических исследованиях по применению этого препарата оправданно. Проводятся также испытания и оценка ряда других лекарственных препаратов по изучению эффективности лечения РТК [55]. Оксалиплатин в самостоятельном режиме или сочетании с 5-ФУ и лейковорином также проявил активность у больных, рефрактерных к 5-ФУ [56—59]

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